Immunology的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列問答集和懶人包總整理

Migration and Homing of Lymphoid Cells: Volume 1

為了解決Immunology的問題，作者 這樣論述：

First published in 1988: This comprehensive set is crucial to the basic understanding of the immune system and is an essential component of the design and implementation of improved immunization strategies. Contains authoritative reviews of cell migration research and addresses the is-sues of lympho

cyte recirculation leading to inductive interactions, and the subsequent migration and homing of effector cells generated from these responses. Systemic migration of cells from the central and peripheral lymphoid organs, the dichotomy of behavior between systemic and mucosal lymphoid cell pools, and

explanations sought for mechanisms mediating selectivity of migration and homing are covered. This set is of interest to problem oriented scientists. Alan J. Husband, Ph.D., is Associate Professor of Immunology in the Faculty of Medicine of the University of Newcastle in Australia.

Immunology進入發燒排行的影片

磁敏釋放控制微膠囊並應用於金屬離子螢光感測

為了解決Immunology的問題，作者杜博瑋 這樣論述：

微膠囊化技術因其在材料科學中的結構和功能性提供眾多優點而近年來受到廣泛的 關注。超分子化學是一門關注分子間非共價鍵作用力的化學學科，從中延伸出了很多 重要的概念和研究方向，例如分子螢光光探針，其螢光特性由其自身的分子結構決定， 但也容易受到環境因素的影響。在該方向上，本論文進行了詳細的研究，解釋了微膠 囊化技術與超分子化學完美的平衡組合，使其具有更好的穩定性和新穎的應用。首先 我們導入超分子化學概念通過一鍋反應合成的芘基衍生物，2­((芘­1­亞甲基) 胺) 乙醇奈 米顆粒，和通過改質的磁性奈米顆粒用作觸發釋放元素通過雙乳化溶劑蒸發法包覆在 聚己內酯聚合物基質構建的微型膠囊中。用於檢測三價陽

離子的開關感測器通過新型 的螢光響應與磁場控制釋放機制被很好地整合在整個系統中，並且在外部震盪磁場下 可以有效地發生熱能與動能的轉換。(1) 通過一鍋法成功合成了具有聚集誘導光增強特性和三價陽離子感測能力的芘基衍 生物螢光探針。我們使用重結晶技術來提高該螢光探針化合物的純度，純度評估由螢 光光譜的半高寬的值確定。通過核磁共振光譜，紫外可見光光譜，螢光光譜和熱重分 析研究了選擇性螢光探針的特性。其聚集誘導光增強特性和對於三價陽離子 (鐵/鋁/鉻) 的選擇開關特性都表現完整且性能良好。在使用這種螢光探針作為核心材料被封裝在 微膠囊中之前，本節充分地研究了其基本特性，穩定的紫外可見光及螢光光譜的結果

是在溶劑 (乙腈) 和水 (100:900; 體積比) 的比例下進行的，強力的激發光在 505 nm，也 分別顯示出其對於三價鐵/鋁/鉻金屬陽離子優異的選擇性。(2) 為了成功通過外部震盪磁場觸發微膠囊的破裂，我們將利用共沉澱法合成並通過 檸檬酸修飾以達到避免團聚現象並提高其穩定性的磁性奈米顆粒嵌入聚合物基質中。 通過由動態光散射所測量到的粒徑分佈和界面電位以及掃描電子顯微鏡觀察到的圖 像，顯示出經過修飾的磁性奈米顆粒具有良好的分散特性和相對未修飾顆粒較小的粒 徑分佈。經過修飾的磁性奈米顆粒和選擇性熒光探針分子通過雙乳化結合溶劑蒸發法 成功封裝在微膠囊中，並通過光學顯微鏡，掃描電子顯微鏡，動

態光散射儀，熱重分i析儀，X 光散射儀，和核磁共振光譜儀對其表面形貌和特征進行了全面的研究。其結 果分別表明被修飾的磁性奈米顆粒和選擇性熒光探針確實有被微膠囊封裝在內，與此 同時，本節還深入討論了殼材料的高分子量的大小，雙乳化的內部水相濃度，以及在 分離微膠囊的離心過程中的離心速率的選擇，對合成微膠囊形貌以及包封效率的影響。 我們發現當聚合物外殼採用的分子量為 80,000 的聚己內酯時，所合成的微膠囊比其他 兩種較低分子量的顯示出更好的包覆效率和更加均勻的形狀，這主要是由於採用較高 分子量的高分子時，其油相在膠囊雙乳化狀態下的固化過程可以提供更好的穩定性。 此外，將溶解在乙腈中 10 mM

的熒光探針化合物作為內部水相的濃度與其他兩種濃度 (0.1 mM, 1 mM) 相比之下，也證明該濃度下所合成的微膠囊具有更好的均勻性和包覆 效率，因為較低濃度的內部水相會導致膠囊外殼內外滲透壓的不穩定。令人驚訝的是， 我們還發現在分離微膠囊的過程中，較高的離心速率會導致微膠囊的多孔性結構的產 生，這種現象可以通過調整較低的離心速率來消除。該策略同時也為未來開發新型多 孔性結構微膠囊的設計提供了一種新的途徑。在本節中，包覆了被修飾後的磁性奈米 顆粒和選擇性螢光探針的微膠囊的釋放行為和感測滴定分別以六十攝氏度的水浴加熱， 機械破壞，和超聲波粉碎的方式模擬其在磁場破裂的條件下進行，並且分別在不同狀

態下完美地測試了其結果。(3) 最後我們巧妙地設計了通過使用外部震盪磁場的方式來觸發芘基席夫鹼螢光 探針在微膠囊中的新型磁感應釋放機制。為了控制膠囊外殼的破裂，分散在乙腈/水 (900:100; 體積比) 中新合成的磁敏微膠囊通過直接感應加熱暴露在高頻磁場下。這些微 膠囊被成功觸發破裂釋放出所包覆的選擇性螢光探針，表現出優異的聚集誘導光增強 特性，和良好的選擇性開關螢光信號用於檢測三價金屬陽離子 (鐵/鋁/鉻)。被釋放的螢 光探針的檢測極限為:2.8602 × 10−6 M (三價鋁離子), 1.5744 × 10−6 M (三價鉻離子)，和 1.8988 × 10−6 M (三價鐵離子)。

該感測器平台也表現出優異的精確度和再現性，如變 異係數所示 (三價鐵離子 ≤ 2.79%, 三價鉻離子 ≤ 2.79%, 三價鋁離子 ≤ 3.76%)，各金屬離 子的回收率分別為:96.5­98.7% (三價鐵離子), 96.7­99.4% (三價鉻離子), 和 94.7­98.9% (三價鋁離子)。以上結果也充分說明了本文所述的控制釋放平台對於三價金屬陽離子 (鐵/鋁/鉻) 活性和實際樣品中的偵測，在未來環境監測甚至生物醫學方面的應用有一定 的價值和潛力。

Nanotechnology Theranostics in Livestock Diseases and Management

為了解決Immunology的問題，作者 這樣論述：

Dr. Minakshi is a Professor in the Department of Animal Biotechnology, LLR University of Veterinary and Animal Sciences (LUVAS), India. Her research interest is in Bioinformatics and Biotechnology with specialization in viruses; molecular characterization, diagnosis and vaccine design, study of geno

me analysis and diversity among viruses. She has been conferred with various prestigious awards notably, International Lifetime Achievement Award 2019 by PISRF(I) in Thailand; International Research Ratna Award, Malaysia. She has more than 20 years of teaching and research experience in Microbiology

and Biotechnology, Molecular Diagnosis, Forensics, Vaccinology, Comparative Genomics, Bioinformatics. She has also published more than 70 research articles in the peer-reviewed international journal and authored or co-authored books and book chapters. She is a member of many international scientifi

c societies and organizations importantly, the National Academy of Agricultural Sciences, India; the National Academy of Veterinary Sciences, International Academy of Biosciences, UK.Dr. Rajesh Kumaris working as Scientist in the Department of Veterinary Physiology and Biochemistry, Lala Lajpat Rai

University of Veterinary and Animal Sciences, Hisar, Haryana, India. Earlier, he was engaged as an Assistant Professor, Kerala Veterinary and Animal Science University, Kerala, India. His research interest is in Reproductive Physiology, Environmental Physiology, Proteomics and Metabolomics, Nanotech

nology, Antioxidant and Redox Biology. Dr. Kumar has to his credit a patent for the development of diagnosis method of anoestrous animals which have genetic linkage. He has been awarded with several prestigious fellowships and worked as referee for several prestigious International journals. He has

authored or co-authored over 40 research articles in the peer-reviewed international journals, several books and book chapters. He is a member of different national and international scientific societies and organizations.Dr. Mayukh Ghosh is an Assistant Professor in the Department of Veterinary Phy

siology and Biochemistry, RGSC, Banaras Hindu University, UP, India. His research interest is in Proteomics and Metabolomics, Nanotechnology, Reproduction, Molecular Parasitology, Antioxidant and Redox Biology. He has authored or co-authored more than 30 research articles in the peer-reviewed intern

ational journals and several books and book chapters. He is a member of several national and international scientific societies and organizations.Dr Shafiq Syed is currently a Lecturer at the University of Newcastle. His research work is focused on defining the molecular pathways involved in the pat

hogenesis of gynaecological cancers, for which he has developed several models including cancer patient-derived-xenograft and -organoid models, and genetically modified mouse-models of cancer progression and metastasis. He has published more than 30 research articles and book chapters. He is a membe

r of the Hunter Cancer Research Alliance (HCRA) and Australian Society of Reproductive Biology.Dr. Soumendu Chakravarti is a Scientist (Sr. Scale) in ICAR-Indian Veterinary Research Institute, Izatnagar, India and has more than 12 years of research and teaching experience in Molecular Virology. He h

as been awarded ICAR International Fellowship and is currently on deputation as a Visiting Scientist, The Pirbright Institute, UK. He is currently working on a project to identify host-restriction factors mediated by Interferon-stimulated genes (ISGs) in virus infections and factors governing specie

s-specific host restriction against viral diseases at the Pirbright Institute. He has published more than 50 research and review articles in peer-reviewed journals. He is a reviewer of several peer reviewed journals and is Life member of several scientific societies such as Society of General Microb

iology (UK), Indian Science Congress Association, Indian Society for Veterinary Immunology and Biotechnology, Veterinary Council of India. ​

透過基於基因本體之整合性分析識別卵巢上皮性腫瘤發病機轉的失調基因功能體

為了解決Immunology的問題，作者蘇國銘 這樣論述：

上皮性卵巢癌（EOCs）在晚期或復發的婦科惡性腫瘤中常是致命的和頑固的，其中漿液性佔絕大多數而卵巢清亮細胞癌（OCCC）是僅次於漿液性上皮性卵巢癌的第二常見的上皮性卵巢癌。即便經過腫瘤減積手術後加上化學藥物治療後仍有不少的患者有著較差的預後或是復發，故整體而言，對於卵巢癌的治療仍是一個相當大的挑戰。此外，邊緣性卵巢腫瘤(BOT)，包括漿液性 BOT與黏液性BOT，是屬於介於良性與惡性之間的卵巢疾病，雖然大部分的預後不差但是也有與卵巢癌不同的組織病理學特性。本研究使用以基因本體(GO)為基礎加上機器學習輔助運算的綜合分析去探討卵巢清亮細胞癌以及漿液性卵巢腫瘤包含漿液性邊緣性卵巢腫瘤與漿液性卵巢

癌的GEO資料庫中失調的基因體、功能途徑，藉以去識別重要的差異表達基因(DEG)。首先在卵巢清亮細胞癌的整合性分析中，發現無論是早期抑或是晚期，與免疫功能相關尤其是活化補體系統的替代途徑的功能失調在腫瘤發生佔有相當重要的關聯性，而補體C3與補體C5也影響了疾病無惡化存活期(Progression-free survival, PFS)和整體存活率(Overall survival, OS)且免疫染色結果是有意義的。而在漿液性卵巢腫瘤的分析中發現，SRC基因和功能失調的芳烴受體(AHR)結合路徑(Binding pathway)確實影響PFS和OS，而且與上皮細胞間質轉化(Epithelial-

mesenchymal transition, EMT)相關的鋅指蛋白SNAI2在腫瘤發生過程中有重要角色，並顯示出從漿液性 BOT 到卵巢癌有著逐漸上升的影響趨勢。未來，標靶治療可以專注於這些有意義的生物標誌並結合精確監測，以提高治療效果和患者存活率。